A REVIEW ON ROLE OF TRPV CATION CHANNELS

  • Deep Sharma Associate Professor, DDM College of Pharmacy, Una, Himachal Pradesh, India, Pincode-177213
  • Rekha Rana Associate Professor ,DDM College of Pharmacy, Una, Himachal Pradesh, India, Pincode-177213
  • Kiran Thakur Assitant Professor DDM College of Pharmacy, Una, Himachal Pradesh, India, Pincode-177213
DOI: https://doi.org/10.32553/jbpr.v10i2.857
Keywords: TRP channels–Vannilloid, TRPV–nociception–thermosensing, Ca2 homeostasis-systemic diseases

Abstract

The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the various diseases.

Published
2021-03-30
How to Cite
Sharma, D., Rana, R., & Thakur, K. (2021). A REVIEW ON ROLE OF TRPV CATION CHANNELS. Journal of Biomedical and Pharmaceutical Research, 10(2), 32-51. https://doi.org/10.32553/jbpr.v10i2.857
Issue
Vol. 10 No. 2 (2021)
Section
Articles

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