PROCESS DEVELOPMENT FOR SYNTHESIZING CEFETAMET SODIUM

  • Mohammed Khalid Ali, Rakesh Kumar Jat

Abstract

The research work relates to an improved and cost effective process for the industrial manufacture of Cefetamet Sodium. More specifically it relates to preparation of products of good quality with high yield and the by products are removed and the same can be recycled using simple industrial and viable method. It can be possible with by using intermediate MAEM to synthesize Cefetamet Sodium. The drug is registered in USP and belongs to 3rd generation drug. There are many patents which gives the procedure of Synthesis of Cefetamet Sodium. These synthesis procedures have taken as standard procedure for pursuing the project work. At present, MAEM is highly used intermediate to synthesis cephalosporin antibiotics. In this project work modification has done for synthesizing  of cephalosporin antibiotics by utilizing MAEM as intermediate and other chemicals like different Lewis acid, and solvent  as alternate  of intermediate, chemicals and solvents which are given in patents to synthesize cephalosporin antibiotics .Resulting yield has improved via making small time synthesis reaction .This is helpful for the commercial purpose. Cephalosporins are the highly used Broad spectrum antibiotics; belong to β-lactam class. The bactericidal action of beta lactam antibiotics is directly attributable to their ability to react with PBP's. The Reaction monitoring was done by HPLC and identification of final product was done by MASS, I.R, NMR and then comparing with the well known literature. Recovery of the side product and byproduct (mercaptobenzothiazole) were achieved to allow a greener process and utilizes for synthesis of other familiar drugs.

Keywords: Cefetamet Sodium, IR, NMR, TLC, HPLC, Mercaptobenzothiazole

Author Biography

Mohammed Khalid Ali, Rakesh Kumar Jat

Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu Rajasthan, 313001, India

Published
2017-02-26
How to Cite
Jat, M. K. A. R. K. (2017). PROCESS DEVELOPMENT FOR SYNTHESIZING CEFETAMET SODIUM. Journal of Biomedical and Pharmaceutical Research, 6(1). Retrieved from http://jbpr.in/index.php/jbpr/article/view/87
Section
Research Articles