Management of Peripheral Neuropathy and Cardiovascular Effects in Vitamin B12 Deficiency

Nishant Kumar  Singh; Hirni J.  Patel; Mohit  Buddhadev; S P Srinivas  Nayak; Gunosindhu  Chakraborthy

doi:10.32553/jbpr.v10i5.884

Nishant Kumar Singh PharmD Student, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat.
Hirni J. Patel PharmD Intern, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat.
Mohit Buddhadev Assistant Professor, Dept. of Pharmacy Practice, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat.
S P Srinivas Nayak Assistant Professor, Dept. of Pharmacy Practice, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat.
Gunosindhu Chakraborthy Professor & Pincipal, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat.

DOI: https://doi.org/10.32553/jbpr.v10i5.884

Keywords: Peripheral Neuropathy, Vitamin B12 Deficiency, Cardiovascular Disease and Homocysteine.

Abstract

Peripheral nerves are susceptible to damage by a wide array of toxins, medications, and vitamin deficiencies. Vitamin B12 (VB12) deficiency neuropathy is a rare debilitating disease that affects mostly the elderly. It is important to consider these etiologies when approaching patients with a variety of neuropathic presentations in this review were have included most relevant and latest information on mechanisms causing Peripheral neuropathy in VB12 deficiency. We also have included cardiovascular disorders and their management. Hyperhomocysteinemia has been implicated in endothelial dysfunction and cardiovascular disease. The association of homocysteine (Hcy) and VB12 with cardiovascular risk factors in patients with coronary artery disease (CAD) has also been studied

Keywords: Peripheral Neuropathy, Vitamin B12 Deficiency, Cardiovascular Disease and Homocysteine.