CHARACTERIZATION, OPTIMIZATION AND FORMULATION OF NIOSOME CONTAINING NAPROXEN

Abstract

Niosomes are vesicular delivery systems which can be formed by aqueous dispersion of non-ionic surfactant films. An effort was made to formulate the Naproxen Niosomes and incorporate the Niosomes into the gel. Formulation F2 showed maximum release while other formulation showed less amount of drug release in 12h. Formulation F5 has highest coefficient of regration (R² =0.998) value and follows drug release by first order model. Hence F2 formulation was the optimized one and found more productive.

 Keywords: Niosomes, Dissolution, Liposomes, Naproxen