ANALYSIS OF THE CLINICAL CHARACTERISTICS OF CHOLE-LITHIASIS AND ITS RELATIONSHIP TO HISTOLOGICAL RESULTS

Abstract

Background: One of the commonest gastro-intestinal ailments and a major financial strain on the healthcare system is gall stone disease. Gallstone formation is facilitated by the bile becoming concentrated and the gallbladder not emptying completely and frequently.

Aims and objectives: In the current study, we looked at the link between histological findings and the clinical characteristics of chole-lithiasis.

Material and Methods: The current research was an observational, prospective, hospital-based study that examined patient gall-bladder samples who had already received a chole-lithiasis clinical diagnosis.

Results: There were 200 total specimens examined. In the fourth decade, there were the most cases. 64 men (32%) and 136 women (68%) participated in our study. Male to female ratio was 1:2, with more women than men. With a ratio of 5.6:1, non-vegetarians were more negatively impacted than vegetarians. In our study, 35% of subjects with a BMI >30 kg/m2 were obese. In 110 patients (or 55%), pain in the right hypochondrium was the most prevalent symptom. In 80% of the instances, multiple stones were the most frequent stones seen. Gross examination revealed that the gall-bladder was thicker in 57% of cases. In our research, the gallstones ranged in size from 0.2 to 3 cm, with the majority measuring 0.2 cm (25%). In our research, chronic nonspecific chole-cystitis was the most prevalent lesion, occurring in 80% of cases. The most frequent types of stones in patients with chronic nonspecific chole-cystitis were mixed stones (71%). In follicular chole-cystitis, pigment stones were common (8%); in xanthogranulomatous chole-cystitis, both pigment and cholesterol stones were present (1%).

Conclusion: Females and non-vegetarians are more likely to have chole-lithiasis. The bulk of the instances had multiple stones, and biochemical research revealed that most of the stones were mixed varieties.

Keywords: chole-lithiasis, multiple stones, biochemical analysis, cholecystectomy, histopathological diagnosis