Preliminary Pharmacognostical & Pharmacological Studies on The Pisonia Grandis R. Br. on Rats

Abstract

The plant Pisonia Grandis R.Br. belongs to the family Nyctaginaceae was taken up for the study by me to screening and gave a report on the possible Pharmacognostical and Pharmacological studies. The various ash values and extract values are determined. In Phytochemical screening showed the nature of the chemical constituents such as Alkaloids, Carbohydrates, Phenolic compounds, Protein and Amino acids, Saponins, Sterols, Flavonoids and Tanins present in the leaf extract of Pisonia Grandis R.Br. The LD50 of the aqueous and alcoholic extracts of Pisonia Grandis R.Br. leaves was found to be 2500 mg/kg. Therefore ED50 was calculated as 250 mg/kg. The Hepatoprotective activity was carried out by the Paracetamol induced model in rats. Administration of the aqueous and alcoholic extracts of Pisonia grandis R.Br. leaves showed significant hepatoprotective activity which was compared with the standared drug silymarin. The effect was more pronounced with the aqueous extracts Pisonia grandis R.Br., this may be probably due to the high contents of flavonoids.

Keywords: Pisonia grandis R.Br , Hepatoprotective, Histopathology, Paracetamol.