Evaluation of Bone Metabolism and Liver Function in Post Renal Transplant Patients

Abstract

Background: Kidneys are responsible for removing extra fluid, minerals, and toxins from the bloodstream as well as maintaining blood pressure. When the kidneys are impaired, toxic wastes pile up in the body, raising blood pressure. It's possible that the body has too much fluid and isn't producing enough red blood cells. Kidney failure is the medical term for this illness. In the case of renal failure, therapy is required to replace the function that the kidneys ordinarily perform. Dialysis or a kidney transplant are the two treatment options available. Each treatment option has advantages and disadvantages. After deciding on a treatment approach, certain lifestyle modifications are required, such as eating and arranging daily activities.

Material and method: The planned study was done at the Department of Surgery as a single-center observational study. Before the patients were enrolled in the trial, they signed a written permission form. Blood samples will be obtained for normal follow-up in all studies. For the aim of taking blood samples, the patients were not exposed to any further intervention. A total of fifteen people had a kidney transplant. The patients' complete medical history, physical examination, and pre-transplant workup were all documented. All metrics were tested after three and six months.

Results: Pre-Renal Transplant Patients had a considerably decreased mean eGFR, as determined by the MDRD equation. Pre-Renal Transplant Patients had considerably higher mean values of Renal Profile Parameters (urea, creatinine, and uric acid). Pre-Renal Transplant Patients had substantially higher mean blood electrolytes parameters (sodium, potassium, chloride) and serum potassium. Pre- Renal Transplant Patients had considerably higher mean blood ALP levels, which might be an additional measure of rapid bone turnover.

Conclusion: According to the findings, continuous follow-up and thorough monitoring of bone mineral metabolites, hematological profile, and liver functions, as well as good patient counseling, can assist provide a holistic treatment to renal transplant patients. The study suggests that more research be done on the long-term effects of the transplanted characteristics. More studies with bigger cohorts and particular patient groups based on age and gender are also suggested.

Keywords: Acute Kidney Injury, Chronic Kidney Disease, GFR, PTH, Renal transplant