Impact of Calcium-Vitamin D Supplements on the Dissolution Pattern of Ranitidine Hydrochloride Tablets: An in vitro Dissolution Study using UV Spectroscopy

  • Tirtha Nandi, Md. Anisur Rahman*, Omer Fayshal Pavel, Sharmin Akhter Liza, Md Ahsanul Huq, Md. J.Haque, Sh. Akter a Department of Pharmacy, East West University, Dhaka, Bangladesh

Abstract

The objective of this study was to evaluate the impact of Calcium-Vitamin D supplement formulations on the dissolution pattern of different Ranitidine Hydrochloride tablet formulations. This was an in-vitro dissolution study using USP apparatus II and UV spectroscopy. Three different brands of Ranitidine hydrochloride i.e. Brand A, Brand B and the innovator brand ‘Zantac®’ were chosen. Besides CS1, CS2 and CS3 were the three Calcium-Vitamin D tablet brands used to carry out the experiments. In our study, all the brands of Ranitidine HCl tablets satisfied the USP requirements by showing dissolution of more than 80% within 60 minutes when tested alone. The dissolution patterns were 98%, 96% and 94% respectively for Brand A, Brand B and ‘Zantac®’. However, their dissolution rates were significantly reduced when they were tested with the Calcium-Vitamin D tablets. With the Brands CS1, CS2 and CS3, the percent drug releases were 50%, 46% and 75% for Brand A, 48%, 49% and 73% for Brand B and 49%, 48% and 72% for ‘Zantac®’. These results may be due to the common ion effects and/or the altered dissolution medium environment. Therefore, this study suggests separate intake of Ranitidine and Calcium supplements to ensure a better therapeutic efficacy.

Keywords: Dissolution, Ranitidine Hydrochloride, Calcium, Vitamin D, UV spectroscopy.

Published
2016-10-30
How to Cite
Ahsanul Huq, Md. J.Haque, Sh. Akter, T. N. M. A. R. O. F. P. S. A. L. M. (2016). Impact of Calcium-Vitamin D Supplements on the Dissolution Pattern of Ranitidine Hydrochloride Tablets: An in vitro Dissolution Study using UV Spectroscopy. Journal of Biomedical and Pharmaceutical Research, 5(5). Retrieved from https://jbpr.in/index.php/jbpr/article/view/129
Section
Research Articles