EFFICACY OF DIPEPTIDYL PEPTIDASE-4 INHIBITOR WITH ZINC AND CHROMIUM PICOLINATE IN PATIENTS OF TYPE-II DIABETES MELLITUS

Abstract

In the present study, we have evaluated the effect of Zinc (Zn) and Chromium picolinate (CrPic) supplementation with sitagliptin in Type-II DM patients. A randomized controlled trial was conducted on 600 patients suffering from Type-II DM. Patients from four different hospitals of Punjab were divided into three groups comprising of 200 patients each. Group A was given sitagliptin (100mg), group B received Zn sulphate (10mg) for 12 weeks along with sitagliptin and group C received CrPic (200mcg) along with sitagliptin. Blood samples of the patients were collected before starting the treatment (zero time sample) and then after 12 weeks of the treatment, to monitor the changes in different study parameters. Blood sugar fasting (BSF) and Glycated hemoglobin (Hb_A1c) was measured by ion exchange chromatography by using a commercial kit (Sigma-Aldrich, St Louis, MO, USA). Analysis of variance (ANOVA) was used to compare the efficacy of all treatment groups. P value ≤ 0.05 was considered significant. Results indicated that all defined therapies have insignificant influence with respect to gender as p = 1.000. BSF and HbA_1c in group B was found effective in all treatments at all levels of study with p=0.000. Our study concludes that Zn supplementation with sitagliptin on glycemic control in patients with Type-II DM gave the best treatment option.

Keywords: BSF, CrPic, Hb_A1C, Type-II DM, Zinc