Pulmonary hypertension; aetio-pathogenesis, current treatment and future prospects

  • Manoj G Tyagi, Jacob Peedicayil*, Usha H Shah, Shailendra K Vajpeyee

Abstract

Pulmonary hypertension (PH) is a vascular disorder characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance, ultimately resulting in pressure overload, dysfunction, and failure of the right ventricle. Current medications for PH do not reverse or completely prevent disease progression, and current diagnostic strategies are suboptimal for detecting early-stages of the disease. One way to optimise the management of PH patients is the use of combination therapy. Another approach to the optimisation of PH management is the development of novel treatments and therapeutic strategies that will provide further opportunities to improve outcomes for PH patients. This article discusses the current and recent advancements in the aetio-pathogenesis and treatment of this disorder.  

Keywords: Pulmonary, hypertension, endothelin, nattokinase, blood pressure, connective

Author Biography

Manoj G Tyagi, Jacob Peedicayil*, Usha H Shah, Shailendra K Vajpeyee

Department of Pharmacology

Jaipur National University, Jaipur & Department of Pharmacology

Christian Medical College*, Vellore, India

Published
2017-08-30
How to Cite
Shailendra K Vajpeyee, M. G. T. J. P. U. H. S. (2017). Pulmonary hypertension; aetio-pathogenesis, current treatment and future prospects. Journal of Biomedical and Pharmaceutical Research, 6(4). Retrieved from https://jbpr.in/index.php/jbpr/article/view/23
Section
Review Articles