A STUDY ON LIPD PROFILE IN PROSTATE CARCINOMA PATIENTS ADMITTED IN AIIMS, NEW DELHI.

Govind Singh1, Sh. Sankanagoudar2, Prem Nath Dogra3, Sandeep R. Mathur4, Nimai C. Chandra4*

Govind Singh1, Sh. Sankanagoudar2, Prem Nath Dogra3, Sandeep R. Mathur4, Nimai C. Chandra4* 1Assistant professor, Department of Biochemistry, Government Medical College, Haldwani Distt- Nainital, Uttarakhand (India) 2Senior resident, Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029, India. 3Professor and head, Department of Urology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029, India. 4Associate professor, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029, India. 5Additional Professor, Department of Biochemistry, All India Institute of Medical Sciences, Patna (Bihar).

Abstract

Prostatic carcinoma is a leading cause of morbidity and mortality in elderly men. Hyper cholesteremia has been classically associated with increased risk of prostate cancer. Recent studies have also shown hypocholesteremic patients raising doubts as whether cholesterol helps in initiating tumour or just consumed more by the tumor cells. These studies have developed a growing consensus whether cholesterol has any role in cell proliferation and tumorogenesis. The present study aims to explore this event. Serum levels of lipids and prostate specific antigen (PSA) were measured in carcinoma prostate, benign prostatic hyperplasia, sham controls (radical cystectomy patients) and normal subjects using enzyme based kit methods. Plasma LDL cholesterol was decreased in carcinogenic specimen(s) as compared to the specimen(s) from normal subjects.

Key words: Cholesterol, LDL receptor, Cell proliferation, Prostate cancer.