IS PSEUDOCHOLINESTERASE RELATED TO LIPID METABOLISM IN CORONARY ARTERY DISEASE?

*Girish M.Desai1, Raghunandana R2, Shreeshail Ghooli3, Netravati Sajjan1

*Girish M.Desai1, Raghunandana R2, Shreeshail Ghooli3, Netravati Sajjan1 1Department of Biochemistry, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India 2Department of Biochemistry, Siddhartha Medical College, Tumkur, Karnataka, India 3Assistant Professor in Department of Community Medicine at Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India

Abstract

Background: Pseudocholinesterase is a serum esterase synthesized by liver. The physiological function of Pseudocholinesterase is not known. It has been proposed that it plays a role in lipid metabolism. Altered lipid metabolism is found in coronary artery disease. Aims and Objectives: To evaluate the association of serum pseudocholinesterase activity with lipid profile in coronary artery disease. Materials and Methods: This cross sectional study comprised 60 subjects, which included equal number of healthy volunteers and myocardial infarction cases. Serum pseudocholinesterase activity and lipid profile was estimated. The data was statistically analyzed. Results: The serum pseudocholinesterase activity, cholesterol, triglycerides and low density lipoprotein were increased in myocardial infarction patients. Serum pseudocholinesterase correlated with the lipid parameters in cases. Conclusion: Increased pseudocholinesterase activity may alter lipid metabolism in coronary artery disease.

Keywords: Pseudocholinesterase; Lipid metabolism; Lipid profile; Coronary artery disease.