UNDISPUTABLE BEHAVIOUR OF LIPID PROFILE IN CHOLELITHIATIC GALL BLADDER

Abstract

In recent years, effort has been made to knowing the pathophysiological basis of gallstone formation. The role of serum lipids in the etiology of cholelithiasis is very important and in cholesterol gallstones serum lipids are altered, hence the aim of this study is to determine and analyze the changes in the lipid profile parameters and atherogenic index in gallstone patients.  This was a cross sectional study conducted in a tertiary care hospital in South India from April 2012 to September 2012. A total of 80 subjects comprising of 40 healthy controls and 40 gallstone cases. In all the subjects, serum lipid profile and atherogenic index estimated. The gallstones received after colesystectomy examined grossly and categorized according to their morphology. Serum total cholesterol, LDL cholesterol and triglycerides levels increased in gall stone patients and HDL cholesterol level was decreased and patients with gallstones atherogenic index was high which is more likely to have additional risk factors for heart disease at young age, particularly in schools and colleges will help in reducing cardiovascular mortality.

Key words: Cholelithiasis, lipid profile, atherogenic index