INVESTIGATION OF RENOPROTECTIVE EFFECT OF EUGENIA CARYOPHYLLATA IN STREPTOZOTOCIN- INDUCED DIABETIC NEPHROPATHY IN WISTAR RATS

Abstract

Essential oil of Eugenia caryophyllata has been proven to show antioxidant, antihyperglycemic, antihyperlipidemic, anti-inflammatory and antidiabetic properties. However its effect on diabetic nephropathy was unexplored. Therefore the present study was designed to investigate the renoprotective effect of Eugenia caryophyllata in streptozotocin induced diabetic nephropathy in Wistar rats. The diabetic rats showed a significant alteration in serum (p<0.05) biochemical parameters such as increase in level of serum glucose, blood urea nitrogen (BUN), creatinine, glycated hemoglobin and decrease in content of serum albumin. Moreover the level of TBARS was increased whereas glutathione level decreased significantly. The lipid profile of diabetic rats was also altered significantly due to increase in serum cholesterol, triglycerides and decline in high density lipoprotein (HDL). Henceforth, from results, it has been concluded that Eugenia caryophyllata has the ability to reduce kidney damage in diabetic rats and the renoprotective effect of Eugenia caryophyllata may be due to its anti-oxidant, hypolipidemic and anti- diabetic activities.