INVESTIGATION OF RENOPROTECTIVE EFFECT OF EUGENIA CARYOPHYLLATA IN STREPTOZOTOCIN- INDUCED DIABETIC NEPHROPATHY IN WISTAR RATS

  • Chand Kaur1, Tapan Behl*2, Rupinder Sodhi1 1Department of Pharmacy, Chandigarh College of Pharmacy, Mohali, Punjab, India 2Department of Pharmacology, Vallabhbhai Patel Chest Institute,University of Delhi, India

Abstract

Essential oil of Eugenia caryophyllata has been proven to show antioxidant, antihyperglycemic, antihyperlipidemic, anti-inflammatory and antidiabetic properties. However its effect on diabetic nephropathy was unexplored. Therefore the present study was designed to investigate the renoprotective effect of Eugenia caryophyllata in streptozotocin induced diabetic nephropathy in Wistar rats. The diabetic rats showed a significant alteration in serum (p<0.05) biochemical parameters such as increase in level of serum glucose, blood urea nitrogen (BUN), creatinine, glycated hemoglobin and decrease in content of serum albumin. Moreover the level of TBARS was increased whereas glutathione level decreased significantly. The lipid profile of diabetic rats was also altered significantly due to increase in serum cholesterol, triglycerides and decline in high density lipoprotein (HDL). Henceforth, from results, it has been concluded that Eugenia caryophyllata has the ability to reduce kidney damage in diabetic rats and the renoprotective effect of Eugenia caryophyllata may be due to its anti-oxidant, hypolipidemic and anti- diabetic activities.

Published
2014-08-30
How to Cite
Rupinder Sodhi1C. K. T. B. (2014). INVESTIGATION OF RENOPROTECTIVE EFFECT OF EUGENIA CARYOPHYLLATA IN STREPTOZOTOCIN- INDUCED DIABETIC NEPHROPATHY IN WISTAR RATS. Journal of Biomedical and Pharmaceutical Research, 3(4). Retrieved from https://jbpr.in/index.php/jbpr/article/view/294
Section
Research Articles