A RANDOMIZED COMPARATIVE STUDY OF PHARMACOLOGICAL EFFECTS OF 1 % TROPICAMIDE WITH 10% PHENYLEPHRINE ON HUMAN EYES

Abstract

Aim and objectives: Comparison of the pharmacological effects like, pupillary diameter, intraocular tension, blood pressure, heart rate, of 1 % Tropicamide with 10 % Phenylephrine eye drops

Methods:  Present studies taken 60 individual patients, were divided into two groups:  Group-1: 30 patients were in this group who received 1% Tropicamide eye drop, Group-2: 30 patients were in this group who received 10% Phenylephrine eye drop. After instillation of drugs on both eyes, pupillary diameter, intraocular tension, blood pressure and heart rate measured with using of various equipments and results were evaluated.

Results: After 45 minutes 1% Tropicamide induced a marked mydriatic effect greater than that produced by 10% phenylephrine with no changes in refraction or visual acuity. IOT was significantly decreased only in normal patients after instillation of 1% tropicamide, whereas 10% phenylephrine shown no statistically significant changes. In the present study there was increased in Blood pressure and Heart rate in Phenylephrine group, when compared with Tropicamide group.

Conclusion: In our study because of rapid onset, brief duration of mydriatic action, greater diffusibility of the drug into cornea, 1% Tropicamide was found to be a better mydriatic than 10% Phenylephrine. Adverse effect like, Blood pressure and heart rate were major drawbacks for Phenylephrine but the overall safety of Tropicamide was better in our study.

Key Words: Mydriatic, 1% Tropicamide, 10% Phenylephrine, PD, IOT, BP, HR