INFLUENCE OF TYPE AND DURATION OF PSORIASIS ON SERUM TOTAL CHOLESTEROL IN SUDANESE PATIENTS ATTENDING KHARTOUM TEACHING HOSPITAL FOR DERMATOLOGY AND VENEREAL DISEASES

Abstract

Background: Psoriasis is an inflammatory dermatosis that is characterized with excessive cellular replication. The high prevalence of atherosclerosis has been reported in psoriatic patients. High serum lipid level has been suggested in the pathogenesis of this phenomenon.

Aims: To evaluate the influence of the type and the duration of psoriasis on serum total cholesterol level. Materials and Methods: the study involved a group of psoriatic patients (N = 79), which were classified into five types of psoriasis. The age range of groups was 18-66 years. Serum cholesterol, concentrations were measured according to the standards. Appropriate statistical tests were used to assess significant difference in the means of the studied concentrations between groups of patients.

Results: The highest cholesterol concentration was observed in psoriatic arthritis (M±SD = 244.3±70 mg/dl), while other types of psoriasis Erythrodermic, Guttate, Plaque, and Inverse shows (M±SD = 243.7±80, 203±34, 190±40, and 192±42 mg/dl, respectively), there was significant positive correlation between the duration of psoriasis and cholesterol concentrations (CC = 0.391, P = 0.001).

Conclusion: This study shows that the highest concentration of serum cholesterol is in psoriatic arthritis, and there is a positive correlation between duration and serum cholesterol concentration.