An Approach Based on Advantages over Conventional System

Abstract

The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Oral delivery is at this time the gold standard in the drug manufacturing where it is considered as the safest, most convenient and greatest economical method of drug delivery. This is seen to affect about 35% of the general population and associated with a number of circumstances like Parkinsonism, mental disability, motion sickness, unconsciousness, unavailability of the water etc. To overcome such difficulties, mouth dissolving tablets have been developed. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” [MDTs] which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants are applicable. The aim of this review article is to give an overview of advantages of Fast-disintegrating tablets over conventional system.

KEYWORDS:  FDT, Patients compliance, super disintigrants, Technology, Evaluation.