Formulation and Characterization of Novel Solid Dispersions of Hydrochlorothiazide by Hot Melt Extrusion Technique

Abstract

The preparation method of Hot melt extrusion involves the treatment of temperature to get the desired properties of the Solid Dispersion. No significant changes has been observed in the physical nature of the both the rochlorothiazide and the carrier. The carrier concentration plays a determining role for in improving solubility of the Hydrochlorothiazide without altering the physical and chemical properties. The carrier selected for the present study was Poloxamer 188 which is very soluble in water and having the capacity to modify the solubility when used along with Hydrochlorothiazide. The preliminary formulations were planned for varying concentration of the Poloxamer 188. The results of the preliminary formulations were promising mainly in drug release pattern and other parameters. The Solid Dispersion of the Hydrochlorothiazide prepared by Hot melt extrusion method using Poloxamer 188 as carrier showed maximum solubility enhancement of Hydrochlorothiazide. The optimum release was found in concentration range of 55%-75%, and was considered for further studies. The final formulations of Solid Dispersion prepared by Hot melt extrusion method were simple and frangible enough to be ground easily. This is indicative of good material handling properties of prepared Solid Dispersion and from the industrial point of view because pulverization of Solid Dispersions is one of the major problems.

KEYWORDS: - Hydrochlorothiazide, Hot-melt extrusion, solid dipsersions