EFFECT OF LACTATE DEHYDROGENASE (LDH) IN PREECLAMPSIA OF PREGANANY

Abstract

Preeclampsia is responsible for significant maternal and perinatal mortality worldwide. Lactate dehydrogenase (LDH) is a multifaceted enzyme whose effects in pregnancy related complications e.g., preeclampsia (PE) is now gaining attention. Here we present evidence that LDH levels could contribute significantly to the outcomes of PE Lactate dehydrogenase is mainly an intracellular enzyme. The levels of LDH in serum are increased in clinical situations associated with cell damage, leak, and hemolysis and cell death. Preeclampsia is such a situation associated with these features. The present study was done to know the levels of serum LDH in preeclampsia patients and if there is an association between these LDH levels and the fetal outcome. A case control study was done with 100 pregnant women diagnosed with preeclampsia and 50 pregnant women without any complications as controls. LDH levels were found to be higher in preeclampsia patients compared to controls. The fetal outcome was poor in the group having high LDH levels. Levels of lactate dehydrogenase as a biochemical marker are easily available test which can be offered to all patients with Hypertension. LDH Levels can be used as a biochemical predicator for the prognosis of preeclampsia.

Keywords: Pregnant women, Preeclampsia, lactate dehydrogenase, LDH.