EVALUATION OF QUALITY OF LIFE IN HEMODIALYSIS PATIENTS   AND MEASUREMENT OF CLINICAL OUTCOMES

Rama Krishna Prudhivi; Shaik Ayesha; Promod Giri; Anuradha .

doi:10.32553/jbpr.v7i4.541

Rama Krishna Prudhivi Department of Pharmacy Practice, Faculty of Pharmacy, Dayananada Sagar University, Bengaluru- 560078, India.
Shaik Ayesha Department of Pharmacy Practice, Dayananda Sagar College of Pharmacy, Bengaluru- 560078, India.
Promod Giri Department of Pharmacy Practice, Dayananda Sagar College of Pharmacy, Bengaluru- 560078, India.
Anuradha . Department of Nephrology, Senior Resident, Sagar Hospitals, Kumaraswamy Layout, Bengaluru- 560078, India.

DOI: https://doi.org/10.32553/jbpr.v7i4.541

Keywords: End stage renal disease, Hemodialysis, Health related quality of life, SF-36 questionnaire.

Abstract

End stage renal disease is the final stage of chronic kidney disease in which the kidneys longer function well enough to meet needs of life. The treatments for ESRD are dialysis or kidney transplant. Hemodialysis (HD) is the most common type of dialysis which can cause significant impairment in health related quality of life (HRQOL) and outcomes. The aim of the present study was to learn about the quality of life in patients receiving dialysis treatment and to evaluate the influence of various factors associated with poor HRQOL. In addition, this study compares SF-36 scores of various domains between survival and deceased patients. The study was a prospective observational, analytical study, conducted for 7 months in IPD/OPD of Dialysis Department at Sagar Hospitals, Bengaluru. The validated and authorized health related quality of life questionnaire (RAND SF-36) consists of 36 questions measuring physical and mental health status was used. Statistical significance of differences in physical component summary and mental component summary was calculated by using Kruskal-Wallis test and the Mann-Whitney U test. A total of 126 patients meeting the study criteria participated and completed the study. Overall, 85(67%) were male and the mean ± standard deviation age was 58.10± 11.38 years. Both PCS and MCS scores have significant negative association with age, total number of chronic medications and the total number of chronic co-morbid diseases. Among eight scales of SF-36, Bodily Pain (BP), Physical Function (PF), Role limitation due to Physical health (RP) and Vitality scores were significantly higher in surviving patients when compared to that of deceased patients respectively. Our study showed that important variables like PF, BP, RP and VT scores can be taken into consideration when dealing with hemodialysis patients. Healthcare providers should be aware of poor physical health as well as mental health among female gender, elderly patients, unemployed patients, patients with no formal education, multiple co-morbid diseases, and multiple chronic medications to improve their quality of life.