Design, Development and Evaluation of Matrix Tablet

Abstract

Recently, sustained release formulations have become a very helpful tool in medical practice, providing patients with a variety of benefits. Sustained release is also a potential method for reducing pharmacological side effects by preventing fluctuations in the concentration of the drug in the plasma. Nowadays, relatively few pharmaceuticals are emerging from research and development, and current drugs are suffering from resistance as a result of their inappropriate usage. Thus, altering the operation is an appropriate and optimum method of increasing the effectiveness of a medicine by a little variation in the drug distribution. The release of the medication through such a system is regulated by both dissolution and diffusion processes. Most medications, if not correctly designed, may quickly release the drug at a higher pace, resulting in hazardous concentrations of the drug upon oral administration. This review discusses the fundamentals of sustained release formulations and the many varieties available.

Key words: Matrix tablets, Sustained release, Sustain release polymers, Patient convenience and compliance.