Formulation and Evaluation Tolbutamide Liposomes for a Sustained Drug Delivery System

Abstract

Novel Drug Delivery system (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. Applications of liposomes in medicine and pharmacology can be divided into diagnostic and therapeutic applications of liposomes containing various markers or drugs. The aim of the study was to formulate and evaluate Tolbutamide liposomes for a sustained drug delivery system. The tolbutamide was prepared as a liposomal drug delivery system by using two different techniques such as physical dispersion method and ether injection method. The morphological characters of prepared liposomes were determined with the help of optical microscope. The results of the particle size showed, when the concentration of soya lecithin was increased the size of the particle was reduced. The in vitro release showed that as the concentration of soya lecithin was increased the release rate of drug was retarded. Among the two methods ether injection method showed prolonged action when compared to physical dispersion method. The stability studies for all the formulations were performed by keeping the formulations at two different temperatures 4ºC±2ºC and 25ºC±2ºC for a period of 30 days. There was no change in morphological characters at 4ºC±2ºC, but there was a slight reduced in particles size at 25ºC±2ºC. The percentage drug entrapment was reduced in all the formulations at both the conditions.