Formulation, Development and Evaluation of Praziquantel Loaded Nanosponges (PZQ-Nsgs) by Using Factorial Design

Raju Balaji  Reddy; Dr. Vinod  Nakra; Dr. Manmeet  Singh Saluja

doi:10.32553/jbpr.v12i1.954

Raju Balaji Reddy Research Scholar, Department of Pharmacy, Sun Rise University, Alwar, Rajasthan, India
Dr. Vinod Nakra Professor, Department of Pharmacy, Sun Rise University, Alwar, Rajasthan, India.
Dr. Manmeet Singh Saluja Professor, Department of Pharmacy, Sun Rise University, Alwar, Rajasthan, India.

DOI: https://doi.org/10.32553/jbpr.v12i1.954

Keywords: Praziquantel, CH guidelines, stability, Analytical techniques, nanosponges

Abstract

Introduction: Praziquantel is used to treat diseases caused by infection with numerous types of internal/gastrointestinal and external parasites. Aim: The aim of this study was to design, formulate and evaluation of Praziquantel loaded nanosponges (PZQ-NSGs) by using factorial design. Methodology: The Determination of Calibration curve by UV visible spectrophotometer and Analytical method validation by UV visible spectrophotometer. The Analytical Techniques Used to Detect Drug-Excipient Compatibility of drug.

Results and Discussion: The developed nanosponge drug delivery system were subjected to stability testing at higher temperature and humidity condition i.e. at 40⁰C ± 2⁰C and RH 75% ± 5 % after 6 months as per ICH guidelines. Solid state characterization of freeze dried PZQ-NSGs have been done with FTIR, PXRD, particle size analysis. From above characterization it was observed that, the sample was remained stable at 40⁰C ± 2⁰C and RH 75% ± 5 % even after 6 months.

Conclusion: Formulated nanosponges formulation was found to be stable at accelerated stability conditions as per ICH guidelines up to 6 months. Nanosized distribution, amorphous nature, better encapsulation and inclusion complexation with EC were found to be the major drivers for significant improvement in solubility, nanosized particles, dissolution efficiency and stability.