USEFULLNESS OF THE MPB-64 GENE BASED STOOL PCR FOR THE DIAGNOSIS OF PULMONARY TUBERCULOSIS IN PEDRIATIC PATIENTS

  • Prem Raj Singh1, Devender Singh Gill1, Preeti Caesar1, Veena Sharma*2 1Auroprobe Laboratories NH-58 Muradnagar, Ghaziabad (U.P), India. 2* Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India.

Abstract

Purpose: Pedriatic pulmonary tuberculosis diagnosis is challenging because young children not able to spontaneously produce sputum. Diagnosis stool for tuberculosis dna from swallowed sputum may diagnose pulmonary tuberculosis. in the present study we evaluate a the mpb-64 gene based stool pcr for the diagnosis of pulmonary tuberculosis in pedriatic patients.

Methods: 149 Pedriatic patients referred for infectious disease consultation with clinical features suggestive of tuberculosis were considered into our study. Culture based diagnosis was considered to be the gold standard against which stool PCR was evaluated.

Results: MPB64 gene based stool PCR had sensitivity of 90.91 % and specificity of 99.1% for confirmed TB cases.

Conclusion: MPB64 gene based stool PCR PCR would be a rapid, non-invasive test for children with suspected pulmonary tuberculosis and an important diagnostic tool for rapid diagnosis of TB.

Published
2013-12-30
How to Cite
Preeti Caesar1, Veena Sharma*2P. R. S. D. S. G. (2013). USEFULLNESS OF THE MPB-64 GENE BASED STOOL PCR FOR THE DIAGNOSIS OF PULMONARY TUBERCULOSIS IN PEDRIATIC PATIENTS. Journal of Biomedical and Pharmaceutical Research, 2(6). Retrieved from http://jbpr.in/index.php/jbpr/article/view/338
Issue
Vol. 2 No. 6 (2013)
Section
Research Articles

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